More Radical Magic with B12: B12-Catalyzed, Light-Induced Cleavage of DNA

被引：7
|
作者：
Kraeutler, Bernhard [1 ,2 ]
Puffer, Barbara
机构：
[1] Univ Innsbruck, Inst Organ Chem, A-6020 Innsbruck, Austria
[2] Univ Innsbruck, Ctr Mol Biosci CMBI, A-6020 Innsbruck, Austria
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 42期
关键词：
bioinorganic chemistry; DNA cleavage; photo-chemistry; radical reactions; reactive oxygen species; vitamins; CHEMISTRY;
D O I：
10.1002/anie.201103373
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
B12 in a new light: The B12 derivative hydroxocobalamin can be used as an efficient catalyst for light-induced strand cleavage of DNA. The proposed radical process involves hydroxy radicals and is controlled by visible light (see scheme). Such light-controlled radical reactions promise to be particularly useful in intracellular applications. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：9791 / 9792
页数：2
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