More Radical Magic with B12: B12-Catalyzed, Light-Induced Cleavage of DNA

被引：7
|
作者：
Kraeutler, Bernhard [1 ,2 ]
Puffer, Barbara
机构：
[1] Univ Innsbruck, Inst Organ Chem, A-6020 Innsbruck, Austria
[2] Univ Innsbruck, Ctr Mol Biosci CMBI, A-6020 Innsbruck, Austria
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 42期
关键词：
bioinorganic chemistry; DNA cleavage; photo-chemistry; radical reactions; reactive oxygen species; vitamins; CHEMISTRY;
D O I：
10.1002/anie.201103373
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
B12 in a new light: The B12 derivative hydroxocobalamin can be used as an efficient catalyst for light-induced strand cleavage of DNA. The proposed radical process involves hydroxy radicals and is controlled by visible light (see scheme). Such light-controlled radical reactions promise to be particularly useful in intracellular applications. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：9791 / 9792
页数：2
相关论文
共 50 条
  • [21] Vitamin B12-catalyzed electro-polymerization for ultrasensitive RNA detection
    Zhao, Yu
    Zhang, Jian
    Ma, Nan
    Kong, Jinming
    Zhang, Xueji
    BIOELECTROCHEMISTRY, 2024, 155
  • [22] On the role of alkylcobalamins in the vitamin B12-catalyzed reductive dehalogenation of perchloroethylene and trichloroethylene
    Pratt, DA
    van der Donk, WA
    CHEMICAL COMMUNICATIONS, 2006, (05) : 558 - 560
  • [23] How B6 helps B12:: The roles of B6, B12, and the enzymes in aminomutase-catalyzed reactions
    Wetmore, SD
    Smith, DM
    Radom, L
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (41) : 10208 - 10209
  • [24] The Light Effect on the Serum B12 Measurement
    Inal, Berrin Bercik
    Sahin, Mustafa
    Usta, Murat
    Aral, Hale
    Emecen, Omer
    Guvenen, Gvenc
    ISTANBUL MEDICAL JOURNAL, 2008, 9 (01): : 6 - 8
  • [25] Effect of Light on Vitamin B12 and Folate
    Clement, Nathan F.
    Kendall, Brian S.
    LABMEDICINE, 2009, 40 (11): : 657 - 659
  • [26] Vitamin B12 protects against DNA damage induced by hydrochlorothiazide
    Alzoubi, Karem H.
    Bayraktar, Erva
    Khabour, Omar
    Al-Azzam, Sayer, I
    SAUDI PHARMACEUTICAL JOURNAL, 2018, 26 (06) : 786 - 789
  • [27] Evaluation of vitamin B12 effects on DNA damage induced by paclitaxel
    Alzoubi, Karem
    Khabour, Omar
    Khader, Manal
    Mhaidat, Nizar
    Al-Azzam, Sayer
    DRUG AND CHEMICAL TOXICOLOGY, 2014, 37 (03) : 276 - 280
  • [28] Evaluation of vitamin B12 effects on DNA damage induced by pioglitazone
    Alzoubi, Karem
    Khabour, Omar
    Hussain, Noor
    Al-Azzam, Sayer
    Mhaidat, Nizar
    MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2012, 748 (1-2) : 48 - 51
  • [29] CONCERNING MECHANISM OF A REACTION CATALYZED BY COENZYME B12
    WHITLOCK, HW
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1963, 85 (15) : 2343 - &
  • [30] Mysteries of Dosing Vitamin B12 and Much More!
    Devi, Sarita
    Sachdev, Harshpal Singh
    Kurpad, Anura Viswanath
    INDIAN PEDIATRICS, 2022, 59 (09) : 677 - 678
12345