Zinc-Triggered Hydrogelation of a Self-Assembling β-Hairpin Peptide

被引：129

作者：

Micklitsch, Christopher M. ^{[2
]}

Knerr, Patrick J. ^{[2
]}

Branco, Monica C. ^{[1
]}

Nagarkar, Radhika ^{[2
]}

Pochan, Darrin J. ^{[2
]}

Schneider, Joel P. ^{[1
]}

机构：

[1] NCI, NIH, Frederick, MD 21701 USA

[2] Univ Delaware, Newark, DE 19716 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 07期

基金：

美国国家科学基金会;

关键词：

hydrogels; materials; peptides; self-assembly; zinc; AMINO-ACIDS; METAL COORDINATION; DESIGNED PEPTIDE; BIOMATERIALS; COMPLEXES; PROTEINS; OXIDE; DRUG;

D O I：

10.1002/anie.201006652

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Zinc-chronized gelling: Selective zinc-triggered hydrogel formation is realized by the self-assembly of a dea novo designed peptide (see picture). A non-natural, zinc-binding aminocarboxylate residue is incorporated into the peptide and is used to trigger folding, assembly, and subsequent gelation. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1577 / 1579

页数：3

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