Zinc-Triggered Hydrogelation of a Self-Assembling β-Hairpin Peptide

被引：129
|
作者：
Micklitsch, Christopher M. [2 ]
Knerr, Patrick J. [2 ]
Branco, Monica C. [1 ]
Nagarkar, Radhika [2 ]
Pochan, Darrin J. [2 ]
Schneider, Joel P. [1 ]
机构：
[1] NCI, NIH, Frederick, MD 21701 USA
[2] Univ Delaware, Newark, DE 19716 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 07期
基金：
美国国家科学基金会;
关键词：
hydrogels; materials; peptides; self-assembly; zinc; AMINO-ACIDS; METAL COORDINATION; DESIGNED PEPTIDE; BIOMATERIALS; COMPLEXES; PROTEINS; OXIDE; DRUG;
D O I：
10.1002/anie.201006652
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Zinc-chronized gelling: Selective zinc-triggered hydrogel formation is realized by the self-assembly of a dea novo designed peptide (see picture). A non-natural, zinc-binding aminocarboxylate residue is incorporated into the peptide and is used to trigger folding, assembly, and subsequent gelation. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1577 / 1579
页数：3
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