Getting better mileage with logically primed CARs

被引：2
|
作者：
Chen, Laurence C. [1 ]
Hou, Andrew J. [1 ]
Chen, Yvonne Y. [1 ,2 ,3 ]
机构：
[1] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Parker Inst Canc Immunotherapy Ctr, Los Angeles, CA 90095 USA
来源：
MED | 2021年 / 2卷 / 07期
基金：
美国国家科学基金会;
关键词：
CELLS;
D O I：
10.1016/j.medj.2021.06.002
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Although remarkably successful against liquid tumors, chimeric anti-gen receptor (CAR)-T cell therapy has been stymied by solid tumors, limited by inadequate specificity and poor efficacy. Pairing synthetic Notch (synNotch) receptors with CARs, Choe et al. and Hyrenius-Wittsten et al. engineer T cells that more precisely and potently combat solid tumors.
引用
收藏
页码：785 / 787
页数：3
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