Getting better mileage with logically primed CARs

被引：2

作者：

Chen, Laurence C. ^{[1
]}

Hou, Andrew J. ^{[1
]}

Chen, Yvonne Y. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Parker Inst Canc Immunotherapy Ctr, Los Angeles, CA 90095 USA

来源：

MED | 2021年 / 2卷 / 07期

基金：

美国国家科学基金会;

关键词：

CELLS;

D O I：

10.1016/j.medj.2021.06.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Although remarkably successful against liquid tumors, chimeric anti-gen receptor (CAR)-T cell therapy has been stymied by solid tumors, limited by inadequate specificity and poor efficacy. Pairing synthetic Notch (synNotch) receptors with CARs, Choe et al. and Hyrenius-Wittsten et al. engineer T cells that more precisely and potently combat solid tumors.

引用

页码：785 / 787

页数：3

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