A structural explanation for the twilight zone of protein sequence homology

被引：101

作者：

Chung, SY

Subbiah, S

机构：

[1] UNIFORMED SERV UNIV HLTH SCI,DEPT BIOCHEM,BETHESDA,MD 20814

[2] STANFORD UNIV,SCH MED,DEPT BIOL STRUCT,STANFORD,CA 94305

来源：

STRUCTURE | 1996年 / 4卷 / 10期

关键词：

D O I：

10.1016/S0969-2126(96)00119-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Homology modeling of protein structures as a function of sequence breaks down at the twilight zone limit of sequence identity between the template and target proteins. Our results suggest that protein sequences that have diverged from a common ancestor beyond the twilight zone may adopt side chain interactions that are very different from those endowed by the ancestral sequence.

引用

页码：1123 / 1127

页数：5

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