Autonomic and metabolic effects of OSA in childhood obesity

被引：4
|
作者：
Oliveira, F. M. [1 ]
Tran, W. H. [1 ]
Lesser, D. [2 ]
Bhatia, R. [3 ]
Ortega, R. [3 ]
Mittelman, S. D. [3 ]
Keens, T. G. [3 ]
Ward, S. L. Davidson [3 ]
Khoo, M. C. [1 ]
机构：
[1] Univ So Calif, Dept Biomed Engn, DRB 140, Los Angeles, CA 90089 USA
[2] Rady Childrens Hosp, San Diego, CA 92123 USA
[3] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA
来源：
2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2010年
关键词：
INSULIN-RESISTANCE; SLEEP;
D O I：
10.1109/IEMBS.2010.5627789
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
This study investigates the effects of exposure to intermittent hypoxia on cardiovascular autonomic control and metabolic function in obese children with obstructive sleep apnea (OSA). Each subject underwent: (1) a polysomnography; (2) morning fasting blood samples and a subsequent FSIVGTT; (3) noninvasive measurement of respiration, arterial blood pressure, and heart rate during supine and standing postures. Assessment of adiposity was performed using a DEXA scan. From these measurements, we deduced the pertinent sleep parameters, Bergman minimal model parameters and the parameters characterizing a minimal model of cardiovascular variability. Results suggest that intermittent hypoxia in OSA contributes independently to insulin resistance and autonomic dysfunction in overweight children.
引用
收藏
页码：6134 / 6137
页数：4
相关论文
共 50 条
  • [31] Childhood Obesity and Autonomic Dysfunction: Risk for Cardiac Morbidity and Mortality
    Liao D.
    Rodríguez-Colón S.M.
    He F.
    Bixler E.O.
    Current Treatment Options in Cardiovascular Medicine, 2014, 16 (10)
  • [32] Cardiac autonomic regulation as a predictor for childhood obesity intervention success
    M J Taylor
    I Vlaev
    D Taylor
    M Kulendran
    P Gately
    H Al-Kuwari
    A Darzi
    M Ahmedna
    International Journal of Obesity, 2017, 41 : 824 - 827
  • [33] Stress and obesity/metabolic syndrome in childhood and adolescence
    Pervanidou, Panagiota
    Chrousos, George P.
    INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY, 2011, 6 : 21 - 28
  • [34] Editorial: Endocrine and metabolic consequences of childhood obesity
    Molnar, Denes
    Mazur, Artur
    Gawlik, Aneta Monika
    Telega, Grzegorz
    Vlachopapadopoulou, Elpis
    Wojcik, Malgorzata
    FRONTIERS IN ENDOCRINOLOGY, 2022, 13
  • [35] Genetic susceptibility to obesity and metabolic syndrome in childhood
    Aguilera, Concepcin M.
    Olza, Josune
    Gil, Angel
    NUTRICION HOSPITALARIA, 2013, 28 : 44 - 55
  • [36] Prevalence of metabolic risk factors in childhood obesity
    Dhuper, S
    Parab, SS
    Sanjev, SA
    Sinisi, J
    St Victor, R
    PEDIATRIC RESEARCH, 2003, 53 (04) : 208A - 208A
  • [37] Thyroid function in childhood obesity and metabolic comorbidity
    Pacifico, Lucia
    Anania, Caterina
    Ferraro, Flavia
    Andreoli, Gian Marco
    Chiesa, Claudio
    CLINICA CHIMICA ACTA, 2012, 413 (3-4) : 396 - 405
  • [38] Childhood Obesity and the Metabolic Syndrome in Developing Countries
    Nidhi Gupta
    Priyali Shah
    Sugandha Nayyar
    Anoop Misra
    The Indian Journal of Pediatrics, 2013, 80 : 28 - 37
  • [39] The effect of obesity on echocardiographic and metabolic parameters in childhood
    Kinik, Sibel Tulgar
    Varan, Birgul
    Yildirim, Selman Vefa
    Tokel, Kursad
    JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2006, 19 (08): : 1007 - 1014
  • [40] Childhood Obesity and the Metabolic Syndrome in Developing Countries
    Gupta, Nidhi
    Shah, Priyali
    Nayyar, Sugandha
    Misra, Anoop
    INDIAN JOURNAL OF PEDIATRICS, 2013, 80 : S28 - S37
12345