Autonomic and metabolic effects of OSA in childhood obesity

被引：4

作者：

Oliveira, F. M. ^{[1
]}

Tran, W. H. ^{[1
]}

Lesser, D. ^{[2
]}

Bhatia, R. ^{[3
]}

Ortega, R. ^{[3
]}

Mittelman, S. D. ^{[3
]}

Keens, T. G. ^{[3
]}

Ward, S. L. Davidson ^{[3
]}

Khoo, M. C. ^{[1
]}

机构：

[1] Univ So Calif, Dept Biomed Engn, DRB 140, Los Angeles, CA 90089 USA

[2] Rady Childrens Hosp, San Diego, CA 92123 USA

[3] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA

来源：

2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2010年

关键词：

INSULIN-RESISTANCE; SLEEP;

D O I：

10.1109/IEMBS.2010.5627789

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This study investigates the effects of exposure to intermittent hypoxia on cardiovascular autonomic control and metabolic function in obese children with obstructive sleep apnea (OSA). Each subject underwent: (1) a polysomnography; (2) morning fasting blood samples and a subsequent FSIVGTT; (3) noninvasive measurement of respiration, arterial blood pressure, and heart rate during supine and standing postures. Assessment of adiposity was performed using a DEXA scan. From these measurements, we deduced the pertinent sleep parameters, Bergman minimal model parameters and the parameters characterizing a minimal model of cardiovascular variability. Results suggest that intermittent hypoxia in OSA contributes independently to insulin resistance and autonomic dysfunction in overweight children.

引用

页码：6134 / 6137

页数：4

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