Association Between Dupilumab Effect on Nasal Polyp Score and Biomarkers of Type 2 Inflammation in Patients with Chronic Rhinosinusitis with Nasal Polyps in the Phase 3 SINUS-24 and SINUS-52 Trials

被引：0
|
作者：
Bachert, C. [1 ]
Corren, J. [2 ]
Lee, S. E. [3 ]
Zhang, H. [4 ]
Harel, S. [5 ]
Cunoosamy, D. [6 ]
Khan, A. H. [5 ]
Jacob-Nara, J. A. [6 ]
Siddiqui, S. [4 ]
Nash, S. [4 ]
机构：
[1] Univ Ghent, Ghent, Belgium
[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
[3] Univ Pittsburgh, Med Ctr, Dept Otolaryngol Head & Neck Surg, Pittsburgh, PA USA
[4] Regeneron Pharmaceut Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
[5] Sanofi, Chilly Mazarin, France
[6] Sanofi, Cambridge, MA USA
来源：
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2021年 / 203卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
A1343
引用
收藏
页数：1
相关论文
共 50 条
  • [31] Dupilumab is associated with lower rates of respiratory infections in patients with chronic rhinosinusitis with nasal polyps-Safety analysis from the SINUS-52 phase 3 trial
    Bachert, C.
    Gevaert, P.
    Lee, S. E.
    Kanesa-Thasan, N.
    Green, S.
    Mannent, L. P.
    Amin, N.
    Chen, Z.
    Lu, X.
    Pandit-Abid, N.
    Ortiz, B.
    ALLERGY, 2020, 75 : 225 - 226
  • [32] Association between the sinus microbiota with eosinophilic inflammation and prognosis in chronic rhinosinusitis with nasal polyps
    Kim, Ji Heui
    Kim, Sung Hee
    Lim, Ji Youn
    Kim, Doyeon
    Jeong, In Seong
    Lee, Dong Kyu
    Jang, Yong Ju
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2020, 52 (06): : 978 - 987
  • [33] Association between the sinus microbiota with eosinophilic inflammation and prognosis in chronic rhinosinusitis with nasal polyps
    Ji Heui Kim
    Sung Hee Kim
    Ji Youn Lim
    Doyeon Kim
    In Seong Jeong
    Dong Kyu Lee
    Yong Ju Jang
    Experimental & Molecular Medicine, 2020, 52 : 978 - 987
  • [34] Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials
    Bachert, Claus
    Han, Joseph K.
    Desrosiers, Martin
    Hellings, Peter W.
    Amin, Nikhil
    Lee, Stella E.
    Mullol, Joaquim
    Greos, Leon S.
    Bosso, John V.
    Laidlaw, Tanya M.
    Cervin, Anders U.
    Maspero, Jorge F.
    Hopkins, Claire
    Olze, Heidi
    Canonica, G. Walter
    Paggiaro, Pierluigi
    Cho, Seong H.
    Fokkens, Wytske J.
    Fujieda, Shigeharu
    Zhang, Mei
    Lu, Xin
    Fan, Chunpeng
    Draikiwicz, Steven
    Kamat, Siddhesh A.
    Khan, Asif
    Pirozzi, Gianluca
    Patel, Naimish
    Graham, Neil M. H.
    Ruddy, Marcella
    Staudinger, Heribert
    Weinreich, David
    Stahl, Neil
    Yancopoulos, George D.
    Mannent, Leda P.
    LANCET, 2019, 394 (10209): : 1638 - 1650
  • [35] Dupilumab (DPL) Improves Upper and Lower Airway Outcomes in Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) with Nonsteroidal Anti-inflammatory Drug-Exacerbated Respiratory Disease (NSAID-ERD): Pooled Results From SINUS-24, SINUS-52 Phase 3 Trials
    Laidlaw, Tanya M.
    Mullol, Joaquim
    Canonica, G. Walter
    Bachert, Claus
    Han, Joseph K.
    Zhang, Mei
    Lu, Xin
    Patel, Naimish
    Graham, Neil Mh
    Staudinger, Heribert
    Mannent, Leda P.
    Amin, Nikhil
    EUROPEAN RESPIRATORY JOURNAL, 2019, 54
  • [36] DUPILUMAB EFFECT ON TYPE 2 INFLAMMATION BIOMARKERS IN CHRONIC RHINOSINUSITIS WITH NASAL POLYPS AND NSAID-ERD
    White, A.
    Fujieda, S.
    Takabayashi, T.
    Daizadeh, N.
    Deniz, Y.
    Rowe, P.
    Mannent, L.
    Amin, N.
    Harel, S.
    Li, Y.
    Jagerschmidt, A.
    ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2020, 125 (05) : S48 - S48
  • [37] Dupilumab Improves Asthma Control as Assessed by Total and Individual Item Scores of the 6-Item Asthma Control Questionnaire in Patients with Severe Chronic Rhinosinusitis with Nasal Polyps and Comorbid Asthma: Pooled Results from the SINUS-24 and SINUS-52 Phase 3 Studies
    Bachert, C.
    Han, J. K.
    Desrosiers, M.
    Hellings, P. W.
    Mao, X.
    Zhang, M.
    Amin, N.
    Mannent, L. P.
    Kamat, S.
    Khan, A. H.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
  • [38] Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials (vol 394, pg 1638, 2019
    Bachert, C.
    Han, J. K.
    Desrosiers, M.
    LANCET, 2019, 394 (10209): : 1618 - 1618
  • [39] Health-Related Quality of Life Impairment Among Patients with Severe Chronic Rhinosinusitis with Nasal Polyps in the SINUS-24 Trial
    Maspero, Jorge F.
    Khan, Asif H.
    Philpott, Carl
    Hellings, Peter W.
    Hopkins, Claire
    Wagenmann, Martin
    Siddiqui, Shahid
    Msihid, Jerome
    Nash, Scott
    Chuang, Chien-Chia
    Kamat, Siddhesh
    Rowe, Paul J.
    Deniz, Yamo
    Jacob-Nara, Juby A.
    JOURNAL OF ASTHMA AND ALLERGY, 2023, 16 : 323 - 332
  • [40] Health-Related Quality of Life Impairment Among Patients With Severe Chronic Rhinosinusitis With Nasal Polyps in the SINUS-24 Trial
    Maspero, Jorge
    Philpott, Carl
    Hellings, Peter
    Hopkins, Claire
    Wagenmann, Martin
    Siddiqui, Shahid
    Jacob-Nara, Juby
    Msihid, Jerome
    Chuang, Chien-Chia
    Kamat, Siddhesh
    Khan, Asif
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2021, 147 (02) : AB133 - AB133
12345