Association Between Dupilumab Effect on Nasal Polyp Score and Biomarkers of Type 2 Inflammation in Patients with Chronic Rhinosinusitis with Nasal Polyps in the Phase 3 SINUS-24 and SINUS-52 Trials

被引:0
|
作者
Bachert, C. [1 ]
Corren, J. [2 ]
Lee, S. E. [3 ]
Zhang, H. [4 ]
Harel, S. [5 ]
Cunoosamy, D. [6 ]
Khan, A. H. [5 ]
Jacob-Nara, J. A. [6 ]
Siddiqui, S. [4 ]
Nash, S. [4 ]
机构
[1] Univ Ghent, Ghent, Belgium
[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
[3] Univ Pittsburgh, Med Ctr, Dept Otolaryngol Head & Neck Surg, Pittsburgh, PA USA
[4] Regeneron Pharmaceut Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
[5] Sanofi, Chilly Mazarin, France
[6] Sanofi, Cambridge, MA USA
关键词
D O I
暂无
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
A1343
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Efficacy and Safety of Dupilumab in Patients with Chronic Rhinosinusitis with Nasal Polyps: Results from the Randomized Phase 3 Sinus-24 Study
    Han, Joseph K.
    Bachert, Claus
    Desrosiers, Martin
    Laidlaw, Tanya M.
    Hopkins, Claire
    Fokkens, Wytske J.
    Paggiaro, Pierluigi
    Cho, Seong Ho
    Olze, Heidi
    Greos, Leon S.
    Zhang, Mei
    Fan, Chunpeng
    Draikiwicz, Steven
    Amin, Nikhil
    Kamat, Siddhesh
    Khan, Asif
    Pirozzi, Gianluca
    Graham, Neil M. H.
    Ruddy, Marcella
    Staudinger, Heribert
    Mannent, Leda P.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 143 (02) : AB422 - AB422
  • [22] Dupilumab efficacy in chronic rhinosinusitis with nasal polyps from SINUS-52 is unaffected by eosinophilic status
    Fujieda, Shigeharu
    Matsune, Shoji
    Takeno, Sachio
    Ohta, Nobuo
    Asako, Mikiya
    Bachert, Claus
    Inoue, Tomoyuki
    Takahashi, Yoshinori
    Fujita, Hiroyuki
    Deniz, Yamo
    Rowe, Paul
    Ortiz, Benjamin
    Li, Yongtao
    Mannent, Leda P.
    ALLERGY, 2022, 77 (01) : 186 - 196
  • [23] Dupilumab Improves Upper and Lower Airway Outcome Measures in Patients with Severe Chronic Rhinosinusitis with Nasal Polyps and Comorbid Asthma: Pooled Results from the SINUS-24 and SINUS-52 Phase 3 Studies
    Laidlaw, T.
    Cho, S.
    Maspero, J. F.
    Canonica, G. W.
    Sher, L.
    Bachert, C.
    Han, J. K.
    Mao, X.
    Zhang, M.
    Patel, N.
    Graham, N. M. H.
    Staudinger, H.
    Mannent, L. P.
    Amin, N.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199
  • [24] Responder analysis to demonstrate the effect of targeting type 2 inflammatory mechanisms with dupilumab across objective and patient-reported endpoints for patients with severe chronic rhinosinusitis with nasal polyps in the SINUS-24 and SINUS-52 studies
    Bachert, Claus
    Peters, Anju T.
    Heffler, Enrico
    Han, Joseph K.
    Olze, Heidi
    Pfaar, Oliver
    Chuang, Chien-Chia
    Rout, Raj
    Attre, Richa
    Goga, Ledia
    Jacob-Nara, Juby A.
    Rowe, Paul J.
    Deniz, Yamo
    Chen, Zhen
    Kamat, Siddhesh
    Siddiqui, Shahid
    CLINICAL AND EXPERIMENTAL ALLERGY, 2022, 52 (02): : 244 - 249
  • [25] Peak nasal inspiratory flow and effect of dupilumab therapy in patients with severe CRSwNP from the SINUS-24 and SINUS-52 studies
    Desrosiers, M.
    Nash, S.
    Lane, A.
    Lee, S.
    De Corso, E.
    Xia, C.
    Khan, A.
    Jacob-Nara, J.
    Sacks, H.
    Rowe, P.
    Deniz, Y.
    ALLERGOLOGIE, 2023, 46 (08) : 549 - 549
  • [26] Dupilumab Improves Sinus Opacification in All Sinuses in Patients With Severe Chronic Rhinosinusitis With Nasal Polyps (CRSwNP): Results From the SINUS-24 Phase 3 Study
    Han, Joseph
    Gross, Gary
    Mannent, Leda
    Amin, Nikhil
    Cho, Seong
    Bachert, Claus
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2020, 145 (02) : AB251 - AB251
  • [27] Dupilumab improves outcomes in patients with chronic rhinosinusitis with nasal polyps irrespective of gender: results from the SINUS-52 trial
    Fokkens, Wytske J.
    Bachert, Claus
    Hopkins, Claire
    Marglani, Osama
    Praestgaard, Amy
    Nash, Scott
    Deniz, Yamo
    Rowe, Paul J.
    Sacks, Harry
    Jacob-Nara, Juby A.
    CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2024, 13 (06)
  • [28] Clinical Efficacy among Patients with Chronic Rhinosinusitis with Nasal Polyps and Clinical Features of Obstructive Lung Disease: Post Hoc Analysis of the Phase III SINUS-24 and SINUS-52 Studies
    Maspero, Jorge F.
    Bachert, Claus
    Martinez, Fernando J.
    Hanania, Nicola A.
    Ortiz, Benjamin
    Patel, Naimish
    Mannent, Leda P.
    Praestgaard, Amy
    Pandit-Abid, Nami
    Siddiqui, Shahid
    Hardin, Megan
    JOURNAL OF ASTHMA AND ALLERGY, 2023, 16 : 333 - 342
  • [29] Lung Function in Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) and Comorbid Asthma with Clinical Features of Chronic Obstructive Pulmonary Disease (COPD): Pooled Analysis of the Phase 3 SINUS-24 and SINUS-52 Studies
    Maspero, J. F.
    Bachert, C.
    Ortiz, B.
    Patel, N.
    Mannent, L. P.
    Daizadeh, N.
    Hardin, M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
  • [30] Dupilumab (DPL) Efficacy in Patients With Severe Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) with/without Nonsteroidal Anti-inflammatory Drug-Exacerbated Respiratory Disease (NSAID-ERD): SINUS-24, SINUS-52 Trials
    Mullol, Joaquim
    Laidlaw, Tanya M.
    Amin, Nikhil
    Bachert, Claus
    Han, Joseph K.
    Hellings, Peter W.
    Canonica, G. Walter
    Cho, Seong H.
    Maspero, Jorge F.
    Desrosiers, Martin
    Hopkins, Claire
    Paggiaro, Pierluigi
    Zhang, Mei
    Lu, Xin
    Patel, Naimish
    Graham, Neil M. H.
    Staudinger, Heribert
    Mannent, Leda P.
    EUROPEAN RESPIRATORY JOURNAL, 2019, 54