Allosteric control of ribozyme catalysis by using DNA constraints

被引：28
|
作者：
Zelin, Elena [1 ]
Silverman, Scott K. [1 ]
机构：
[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
来源：
CHEMBIOCHEM | 2007年 / 8卷 / 16期
关键词：
RNA TERTIARY STRUCTURE; HAMMERHEAD RIBOZYME; CROSS-LINKING; 1ST STEP; DEOXYRIBOZYME; MIMICKING; KINASE; ENZYME; DOMAIN;
D O I：
10.1002/cbic.200700437
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Strings attached. Covalent attachment of two DNA strands to RNA enabled allosteric control of hammerhead ribozyme catalysis by formation of a double-stranded DNA constraint, as illustrated in the figure. The constraint acted by disrupting RNA tertiary structure while leaving the secondary structure essentially intact.
引用
收藏
页码：1907 / +
页数：6
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