Allosteric control of ribozyme catalysis by using DNA constraints

被引：28
|
作者：
Zelin, Elena [1 ]
Silverman, Scott K. [1 ]
机构：
[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
来源：
CHEMBIOCHEM | 2007年 / 8卷 / 16期
关键词：
RNA TERTIARY STRUCTURE; HAMMERHEAD RIBOZYME; CROSS-LINKING; 1ST STEP; DEOXYRIBOZYME; MIMICKING; KINASE; ENZYME; DOMAIN;
D O I：
10.1002/cbic.200700437
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Strings attached. Covalent attachment of two DNA strands to RNA enabled allosteric control of hammerhead ribozyme catalysis by formation of a double-stranded DNA constraint, as illustrated in the figure. The constraint acted by disrupting RNA tertiary structure while leaving the secondary structure essentially intact.
引用
收藏
页码：1907 / +
页数：6
相关论文
共 50 条
  • [21] Catalysis in the Varkud satellite ribozyme
    Ganguly, Abir
    York, Darrin
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
  • [22] Nucleobase catalysis in ribozyme mechanism
    Bevilacqua, Philip C.
    Yajima, Rieko
    CURRENT OPINION IN CHEMICAL BIOLOGY, 2006, 10 (05) : 455 - 464
  • [23] Nucleobase participation in ribozyme catalysis
    Zhao, ZY
    McLeod, A
    Harusawa, S
    Araki, L
    Yamaguchi, M
    Kurihara, T
    Lilley, DMJ
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (14) : 5026 - 5027
  • [24] Folding and catalysis by the hairpin ribozyme
    Lilley, DMJ
    FEBS LETTERS, 1999, 452 (1-2) : 26 - 30
  • [25] Crystallographic structures of the hammerhead ribozyme: Relationship to ribozyme folding and catalysis
    Wedekind, JE
    McKay, DB
    ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1998, 27 : 475 - 502
  • [26] Conditional RNA Interference Mediated by Allosteric Ribozyme
    Kumar, Deepak
    An, Chung-Il
    Yokobayashi, Yohei
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (39) : 13906 - +
  • [27] On/off regulation of catalysis by allosteric control of metal complex nuclearity
    Kovbasyuk, L
    Pritzkow, H
    Krämer, R
    Fritsky, IO
    CHEMICAL COMMUNICATIONS, 2004, (07) : 880 - 881
  • [28] Conditional RNA interference mediated by allosteric ribozyme
    Kumar, Deepak
    An, Chung-Il
    Yokobayashi, Yohei
    Journal of the American Chemical Society, 2009, 131 (39): : 13906 - 13907
  • [29] Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructure
    Mao, Xiuhai
    Simon, Anna J.
    Pei, Hao
    Shi, Jiye
    Li, Jiang
    Huang, Qing
    Plaxco, Kevin W.
    Fan, Chunhai
    CHEMICAL SCIENCE, 2016, 7 (02) : 1200 - 1204
  • [30] RNA structure - Ribozyme crevices and catalysis
    Herschlag, D
    NATURE, 1998, 395 (6702) : 548 - 549
12345