Direct carboxamidation of indoles by palladium-catalyzed C-H activation and isocyanide insertion

被引：102
|
作者：
Peng, Jiangling [1 ,2 ]
Liu, Lanying [1 ,2 ]
Hu, Ziwei [1 ,2 ]
Huang, Jinbo [1 ,2 ]
Zhu, Qiang [1 ,2 ]
机构：
[1] Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed, 190 Kaiyuan Ave, Guangzhou 510530, Guangdong, Peoples R China
[2] Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Hlth, Guangzhou 510530, Guangdong, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 31期
基金：
美国国家科学基金会;
关键词：
FUNCTIONALIZATION; AMIDATION; MILD; 4-AMINOQUINAZOLINES; ALKENYLATION; HETEROARENES; ANNULATION; CYANATION; BONDS;
D O I：
10.1039/c2cc30351e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A selective C3 carboxamidation of indoles including free (N-H) ones by palladium-catalyzed sequential C-H activation-isocyanide insertion has been developed.
引用
收藏
页码：3772 / 3774
页数：3
相关论文
共 50 条
  • [31] Double C-H Activation: The Palladium-Catalyzed Direct C-Arylation of Xanthines with Arenes
    Malakar, Chandi C.
    Schmidt, Dietmar
    Conrad, Juergen
    Beifuss, Uwe
    ORGANIC LETTERS, 2011, 13 (06) : 1378 - 1381
  • [32] Synthesis of 4-aminoquinolines by aerobic oxidative palladium-catalyzed double C–H activation and isocyanide insertion
    T. Vlaar
    B. U. W. Maes
    E. Ruijter
    R. V. A. Orru
    Chemistry of Heterocyclic Compounds, 2013, 49 : 902 - 908
  • [33] Enhancing the regioselectivity of C-H activation in palladium-catalyzed direct arylation polymerization (DARP)
    Woods, Keenan
    Wiley, Calvin
    Simmons, Bryan
    Boggess, Steven
    Rudenko, Andrey
    Thompson, Barry C.
    Tannaci, John F.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [34] Mild and Efficient Palladium-Catalyzed Direct Trifluoroethylation of Aromatic Systems by C-H Activation
    Toth, Balazs L.
    Kovacs, Szabolcs
    Salyi, Gergo
    Novak, Zoltan
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (06) : 1988 - 1992
  • [35] Palladium-Catalyzed Triple Successive C-H Functionalization: Direct Synthesis of Functionalized Carbazoles from Indoles
    Verma, Akhilesh K.
    Danodia, Abhinandan K.
    Saunthwal, Rakesh K.
    Patel, Monika
    Choudhary, Deepak
    ORGANIC LETTERS, 2015, 17 (15) : 3658 - 3661
  • [36] Palladium-Catalyzed Domino Heck/C-H Activation/Intermolecular Direct Arylation Reactions
    Lu, Zhiyao
    Cui, Yuxin
    Jia, Yanxing
    SYNTHESIS-STUTTGART, 2011, (16): : 2595 - 2599
  • [37] Palladium-Catalyzed Direct Arylation of Azulene Based on Regioselective C-H Bond Activation
    Murai, Masahito
    Yanagawa, Mayu
    Nakamura, Masahiro
    Takai, Kazuhiko
    ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 5 (05) : 629 - 635
  • [38] Palladium-Catalyzed Cascade Reactions for Annulative π-Extension of Indoles to Carbazolcs through C-H Bond Activation
    Dinda, Enakshi
    Bhunia, Samir Kumar
    Jana, Ranjan
    CURRENT ORGANIC CHEMISTRY, 2020, 24 (22) : 2612 - 2633
  • [39] Indoles from Simple Anilines and Alkynes: Palladium-Catalyzed C-H Activation Using Dioxygen as the Oxidant
    Shi, Zhuangzhi
    Zhang, Chun
    Li, Si
    Pan, Delin
    Ding, Shengtao
    Cui, Yuxin
    Jiao, Ning
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (25) : 4572 - 4576
  • [40] Palladium-catalyzed direct and regioselective C-H acyloxylation of indolizines
    Sun, Jinwei
    Wang, Fuyao
    Shen, Yongmiao
    Zhi, Huizhen
    Wu, Hui
    Liu, Yun
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 13 (40) : 10236 - 10243
12345