Stereocontrolled α-alkylation of oxime ether derived from terpene:: Efficient synthesis of new chiral γ- and δ-amino alcohols

被引：8

作者：

Jennequin, Thomas ^{[2
]}

Labat, Stephane ^{[2
]}

Toupet, Loic ^{[3
]}

Caille, Jean-Claude ^{[1
]}

Mauduit, Marc ^{[2
]}

机构：

[1] Zambon ZI Croix Cadeau, F-49243 Avrille, France

[2] Ecole Natl Super Chim Rennes, Equipe Chim Org & Supramol, CNRS, UMR 6226, F-35700 Rennes, France

[3] CNRS, UMR 6626, Grp Matiere Condensee & Mat, F-35042 Rennes, France

来源：

SYNLETT | 2008年 / 11期

关键词：

oxime ether; (+)-nopinone; stereocontrolled alkylation; amino alcohols;

D O I：

10.1055/s-2008-1078492

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The alkylation of (+)-nopinone oxime ether with various electrophiles afforded the corresponding adduct with a total stereoselectivity. Further reduction of the oxime ether afforded an easily access to new chiral gamma-and delta-amino alcohols of high interest for catalysis and asymmetric synthesis.

引用

页码：1669 / 1672

页数：4

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