Efficient synthesis of chiral benzofuryl β-amino alcohols via a catalytic asymmetric Henry reaction

被引：18

作者：

Chen, Wei ^{[1
]}

Zhou, Zhao-Hui ^{[1
]}

Chen, Hong-Bin ^{[1
]}

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 06期

关键词：

BLOCKING-AGENT; BUFURALOL-HCL; COMPLEX; PROPAFENONE; ALDEHYDES; (S)-BUFURALOL; PROPRANOLOL; RESISTANCE; ANALOGS;

D O I：

10.1039/c6ob02569b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral beta-amino alcohol ligands were found effective for the copper(II)-catalyzed asymmetric Henry reaction of benzofuran-2-carbaldehydes with nitromethane, which led to the formation of (S)-enriched benzofuryl beta-nitro alcohols with satisfactory enantioselectivities (up to 98% ee). Using this catalytic protocol, bioactive (S)-benzofuryl beta-amino alcohols could be conveniently prepared in short steps.

引用

页码：1530 / 1536

页数：7

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