Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose? Commentary

被引：110
|
作者：
Reusch, JEB
机构：
[1] Vet Affairs Med Ctr, Endocrinol Sect 111H, Denver, CO 80220 USA
[2] Univ Colorado, Hlth Sci Ctr, Div Endocrinol Diabet & Metab, Dept Med, Denver, CO USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 07期
关键词：
D O I：
10.1172/JCI200319902
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Glycemic control is the primary mediator of diabetic microvascular complications and also contributes to macrovascular complications. A new study (see related article beginning on page 1049) reveals a previously unrecognized association between oxidant activation of poly(ADP ribose) polymerase (PARP) and upregulation of known mediators of glycemic injury. Inhibitors of PARP may have potential therapeutic roles in the prevention of diabetic complications.
引用
收藏
页码：986 / 988
页数：3
相关论文
共 50 条
  • [41] Cardiovascular complications in diabetes mellitus
    Sobel, BE
    Schneider, DJ
    CURRENT OPINION IN PHARMACOLOGY, 2005, 5 (02) : 143 - 148
  • [42] Diabetes prevention and cardiovascular complications
    Silvio E. Inzucchi
    Catherine M. Viscoli
    Lawrence H. Young
    Walter N. Kernan
    Diabetologia, 2019, 62 : 2161 - 2162
  • [43] Markers of inflammation are associated with microvascular complications and cardiovascular disease in Type 1 diabetes - the EURODIAB Prospective Complications study.
    Schram, MT
    Chaturvedi, N
    Schalkwijk, CG
    Fuller, JH
    Stehouwer, CDA
    DIABETOLOGIA, 2003, 46 : A43 - A43
  • [44] Microvascular and macrovascular complications Microvascular and macrovascular complications
    Donaghue, Kim C.
    Chiarelli, Francesco
    Trotta, Daniela
    Allgrove, Jeremy
    Dahl-Jorgensen, Knut
    PEDIATRIC DIABETES, 2007, 8 (03) : 163 - 170
  • [45] Commentary on prevention of cardiovascular complications in diabetes mellitus as novel inidication for Diabeton MR
    Vikulova, O. K.
    DIABETES MELLITUS, 2012, 15 (02): : 84 - 88
  • [46] BLOOD-GLUCOSE CONTROL AND MICROVASCULAR COMPLICATIONS - WHAT DO WE DO NOW
    DAHLJORGENSEN, K
    BRINCHMANNHANSEN, O
    BANGSTAD, HJ
    HANSSEN, KF
    DIABETOLOGIA, 1994, 37 (12) : 1172 - 1177
  • [47] PLASMA URATE IN DIABETES - RELATIONSHIP TO GLYCEMIA, GLUCOSE DISPOSAL, MICROVASCULAR COMPLICATIONS AND THE VARIATIONS FOLLOWING ORAL GLUCOSE
    OLUKOGA, AO
    ERASMUS, RT
    AKINLADE, KS
    OKESINA, AB
    ALANAMU, AA
    ABU, EA
    DIABETES RESEARCH AND CLINICAL PRACTICE, 1991, 14 (02) : 99 - 105
  • [48] Do statins reduce microvascular complications in diabetes?
    Preiss, David
    LANCET DIABETES & ENDOCRINOLOGY, 2014, 2 (11): : 858 - 859
  • [49] Microvascular Complications of Diabetes: Nephropathy, Retinopathy, and Maculopathy
    Pistrosch, F.
    Furashova, O.
    Engelmann, K.
    Hanefeld, M.
    DIABETES STOFFWECHSEL UND HERZ, 2018, 27 (01): : 24 - 32
  • [50] Haemodynamics in microvascular complications in type 1 diabetes
    Candido, R
    Allen, TJ
    DIABETES-METABOLISM RESEARCH AND REVIEWS, 2002, 18 (04) : 286 - 304
12345