Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose? Commentary

被引：110
|
作者：
Reusch, JEB
机构：
[1] Vet Affairs Med Ctr, Endocrinol Sect 111H, Denver, CO 80220 USA
[2] Univ Colorado, Hlth Sci Ctr, Div Endocrinol Diabet & Metab, Dept Med, Denver, CO USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 07期
关键词：
D O I：
10.1172/JCI200319902
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Glycemic control is the primary mediator of diabetic microvascular complications and also contributes to macrovascular complications. A new study (see related article beginning on page 1049) reveals a previously unrecognized association between oxidant activation of poly(ADP ribose) polymerase (PARP) and upregulation of known mediators of glycemic injury. Inhibitors of PARP may have potential therapeutic roles in the prevention of diabetic complications.
引用
收藏
页码：986 / 988
页数：3
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