Crosstalk in the Retinal Neurovascular Unit - Lessons for the Diabetic Retina

被引：30
|
作者：
Feng, Y. [1 ,2 ]
Busch, S. [1 ]
Gretz, N. [3 ]
Hoffmann, S. [3 ]
Hammes, H. -P. [1 ]
机构：
[1] Univ Heidelberg, Med Fac Mannheim, Dept Med 5, D-68167 Mannheim, Germany
[2] Univ Heidelberg, Med Fac Mannheim, Inst Expt & Clin Pharmacol & Toxicol, D-68167 Mannheim, Germany
[3] Univ Heidelberg, Med Fac Mannheim, Med Res Ctr, D-68167 Mannheim, Germany
来源：
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2012年 / 120卷 / 04期
关键词：
diabetes; oxidative stress; neuropathy; reknopathy; RAT RETINA; CELL-DEATH; RETINOPATHY; COMPLICATIONS; POLYCYSTIN-2; DEGENERATION; SUPEROXIDE; EXPRESSION; RECEPTOR; DISEASE;
D O I：
10.1055/s-0032-1304571
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetic retinopathy shares important features with neurodegenerative retinal diseases, including loss of ganglion cells and retinal thinning. The impact on vasoregression and subsequent ischemia-driven changes such as macular edema and proliferative retinopathy are not established. Studies using adult neurodegenerative animal models such as the transgenic TGR(CMV-PKD2((1/703))HA) rat imply early activation of the innate immunity system and the complement system as well as microglia playing a role in the damage of the retinal neurovascular unit.
引用
收藏
页码：199 / 201
页数：3
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