Crosstalk in the Retinal Neurovascular Unit - Lessons for the Diabetic Retina

被引：30

作者：

Feng, Y. ^{[1
,2
]}

Busch, S. ^{[1
]}

Gretz, N. ^{[3
]}

Hoffmann, S. ^{[3
]}

Hammes, H. -P. ^{[1
]}

机构：

[1] Univ Heidelberg, Med Fac Mannheim, Dept Med 5, D-68167 Mannheim, Germany

[2] Univ Heidelberg, Med Fac Mannheim, Inst Expt & Clin Pharmacol & Toxicol, D-68167 Mannheim, Germany

[3] Univ Heidelberg, Med Fac Mannheim, Med Res Ctr, D-68167 Mannheim, Germany

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2012年 / 120卷 / 04期

关键词：

diabetes; oxidative stress; neuropathy; reknopathy; RAT RETINA; CELL-DEATH; RETINOPATHY; COMPLICATIONS; POLYCYSTIN-2; DEGENERATION; SUPEROXIDE; EXPRESSION; RECEPTOR; DISEASE;

D O I：

10.1055/s-0032-1304571

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic retinopathy shares important features with neurodegenerative retinal diseases, including loss of ganglion cells and retinal thinning. The impact on vasoregression and subsequent ischemia-driven changes such as macular edema and proliferative retinopathy are not established. Studies using adult neurodegenerative animal models such as the transgenic TGR(CMV-PKD2((1/703))HA) rat imply early activation of the innate immunity system and the complement system as well as microglia playing a role in the damage of the retinal neurovascular unit.

引用

页码：199 / 201

页数：3

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