Synthesis of some novel 3-(2-chloro-3-quinolyl)-5-phenyl [1,3] thiazolo [2,3-c] [1,2,4] triazoles

被引：0
|
作者：
Dubey, PK [1 ]
Rao, SS [1 ]
Aparna, V [1 ]
机构：
[1] JNT Univ, Coll Engn, Dept Chem, Hyderabad 500072, Andhra Pradesh, India
来源：
HETEROCYCLIC COMMUNICATIONS | 2003年 / 9卷 / 03期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Various acetanilides (1) were treated with DMF and POCl3 complex (Vilsmeier's reagent) to obtain 2-chloro-3-quinolinecarboxaldehydes (2). The latter on condensation with thiosemi- carbazide in alcohol gave the corresponding thiosemicarbazones (3), which on treatment with substituted phenacyl bromides (4) in alchol gave quinoline substituted thiazoles (5). The dehydrogenative cyclisation of 5 was achieved with chloranil in refluxing toluene resulting in novel 3-(2-chloro-3-quinolyl)-6-phenyl [1,3] thiazolo [2,3-c] [1,2,4] triazoles (6) whose structures are supported by spectral data.
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页码：281 / 286
页数：6
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