An efficient synthesis for pyrimido[4',5':4,5]thieno[2,3-c]pyridazine derivatives via intramolecular Aza-Wittig reaction-heterocyclization strategy

被引：0

作者：

Quintela, JM

AlvarezSarandes, R

Veiga, MC

Peinador, C

机构：

来源：

HETEROCYCLES | 1997年 / 45卷 / 07期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ready one-pot preparation for substituted pyrimidothienopyridazines is reported. Aza-Wittig reaction of iminophosphorane (3), derived from ethyl 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylate (2), with isocyanates, followed by heterocyclization on addition of amines provided a novel synthetic route to the functionalized pyrimido[4',5':4,5]thieno[2,3-c]pyridazines (6). The guanidine-type intermediate compounds (5) derived from addition of amines to the carbodiimides (4) could be isolated and characterized, thus confirming the suggest reaction pathway.

引用

页码：1319 / 1336

页数：18

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