An efficient synthesis for pyrimido[4',5':4,5]thieno[2,3-c]pyridazine derivatives via intramolecular Aza-Wittig reaction-heterocyclization strategy

被引：0
|
作者：
Quintela, JM
AlvarezSarandes, R
Veiga, MC
Peinador, C
机构：
来源：
HETEROCYCLES | 1997年 / 45卷 / 07期
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暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A ready one-pot preparation for substituted pyrimidothienopyridazines is reported. Aza-Wittig reaction of iminophosphorane (3), derived from ethyl 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylate (2), with isocyanates, followed by heterocyclization on addition of amines provided a novel synthetic route to the functionalized pyrimido[4',5':4,5]thieno[2,3-c]pyridazines (6). The guanidine-type intermediate compounds (5) derived from addition of amines to the carbodiimides (4) could be isolated and characterized, thus confirming the suggest reaction pathway.
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页码：1319 / 1336
页数：18
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