A new bioactive ursane-type triterpenoid from Croton bonplandianum Bail

被引：13
|
作者：
Ghosh, Pranab [1 ]
Mandal, Amitava [1 ]
Rasul, Mohammad Golam [1 ]
机构：
[1] Univ N Bengal, Dept Chem, Darjeeling 734013, India
来源：
JOURNAL OF CHEMICAL SCIENCES | 2013年 / 125卷 / 02期
关键词：
Croton bonplandianum; 3 alpha-hydroxy-urs-12,15-dien; antifungal; ACID;
D O I：
10.1007/s12039-013-0387-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new triterpenoid 3 alpha-hydroxy-urs-12,15-dien (1) of ursane skeleton along with three others, viz. oleanolic acid (2) and ursolic acid (3) and beta-sitosterol (4) were isolated from the root of Croton bonplandianum Bail. Their chemical structures were established on the basis of spectroscopic analysis (IR, 1D NMR, 2D NMR, Mass, etc.) and by chemical means. A probable biosynthetic pathway of compound 1 was also proposed. Preliminary investigation with the new compound showed potent activity against a series of fungal pathogens.
引用
收藏
页码：359 / 364
页数：6
相关论文
共 50 条
  • [41] Glycosides of ursane-type triterpenoid, benzophenone, and iridoid from Vangueria agrestis (Fadogia agrestis) and their anti-infective activities
    Osman, Ahmed Galal
    Ali, Zulfiqar
    Fantoukh, Omer
    Raman, Vijayasankar
    Kamdem, Ramsay S. T.
    Khan, Ikhlas
    NATURAL PRODUCT RESEARCH, 2020, 34 (05) : 683 - 691
  • [42] Four new ursane-type saponins from Morina nepalensis var. alba
    Teng, RW
    Xie, HY
    Wang, DZ
    Yang, CR
    MAGNETIC RESONANCE IN CHEMISTRY, 2002, 40 (09) : 603 - 608
  • [43] Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities
    Mei Yu-Dan
    Zhang Nan
    Zhang Wei-Yang
    Tang Jin-Shan
    Zhou Hua
    Yu Yang
    Yao Xin-Sheng
    CHINESE JOURNAL OF NATURAL MEDICINES, 2019, 17 (01) : 27 - 32
  • [44] Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities
    MEI Yu-Dan
    ZHANG Nan
    ZHANG Wei-Yang
    TANG Jin-Shan
    ZHOU Hua
    YU Yang
    YAO Xin-Sheng
    ChineseJournalofNaturalMedicines, 2019, 17 (01) : 27 - 32
  • [45] Two new 20α(H)-ursane-type triterpenoids from Ilex cornuta and their cytotoxic activities
    Wang, Wen-Lian
    Zhou, Xi
    Liu, Yan-Li
    Xu, Qiong-Ming
    Li, Xiao-Ran
    Yang, Shi-Lin
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2014, 16 (02) : 175 - 180
  • [46] A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells
    Nguyen Xuan Nhiem
    Bui Huu Tai
    Tran Hong Quang
    Phan Van Kiem
    Chau Van Minh
    Nguyen Hoai Nam
    Kim, Jun-Ho
    Im, Lee-Rang
    Lee, Young-Mi
    Kim, Young Ho
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (06) : 1777 - 1781
  • [47] Ursane-type triterpenes from Rubus wallichianus Wight & Arn and their chemotaxonomic significance
    He, Jiang-bo
    Kang, Da-wei
    Niu, Yan-fen
    Wang, Ji-ai
    Bi, Xiao-xu
    Chen, Xiu
    Cao, Yan-ru
    Luan, Jie
    BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2022, 104
  • [48] Plectraterpene, a new ursane-type triterpene ester and other steroids from the aerial parts of Plectranthus montanus
    Musarat Amina
    Nawal M. Al Musayeib
    Gamal A. Mohamed
    Sabrin R. M. Ibrahim
    Revista Brasileira de Farmacognosia, 2017, 27 : 698 - 701
  • [49] Three new ursane-type triterpenoids from the roots of Sanguisorba officinalis L. and their cytotoxic activity
    Wang, Rongshen
    Jin, Mei
    Jin, Chunshi
    Sun, Jinfeng
    Ye, Chao
    Zong, Tieqiang
    Chen, Guoqing
    Zhou, Wei
    Li, Gao
    PHYTOCHEMISTRY LETTERS, 2019, 32 : 96 - 100
  • [50] Structural elucidation of two new ursane-type triterpenoids from Syzygium handelii by spectroscopic analyses and calculations
    Liu, Feifei
    Huang, Shuheng
    Teng, Baorui
    Zhang, Yifeng
    Zhou, Xin
    Liu, Sijing
    Zhang, Dan
    Li, Zhi
    Lei, Hui
    JOURNAL OF MOLECULAR STRUCTURE, 2024, 1317
12345