A new bioactive ursane-type triterpenoid from Croton bonplandianum Bail

被引：13
|
作者：
Ghosh, Pranab [1 ]
Mandal, Amitava [1 ]
Rasul, Mohammad Golam [1 ]
机构：
[1] Univ N Bengal, Dept Chem, Darjeeling 734013, India
来源：
JOURNAL OF CHEMICAL SCIENCES | 2013年 / 125卷 / 02期
关键词：
Croton bonplandianum; 3 alpha-hydroxy-urs-12,15-dien; antifungal; ACID;
D O I：
10.1007/s12039-013-0387-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new triterpenoid 3 alpha-hydroxy-urs-12,15-dien (1) of ursane skeleton along with three others, viz. oleanolic acid (2) and ursolic acid (3) and beta-sitosterol (4) were isolated from the root of Croton bonplandianum Bail. Their chemical structures were established on the basis of spectroscopic analysis (IR, 1D NMR, 2D NMR, Mass, etc.) and by chemical means. A probable biosynthetic pathway of compound 1 was also proposed. Preliminary investigation with the new compound showed potent activity against a series of fungal pathogens.
引用
收藏
页码：359 / 364
页数：6
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