A sesquiterpene glycoside and phenylalanine derivatives from Tinospora sinensis

被引：10
|
作者：
Huang, Liping [1 ]
Luo, Dezhi [1 ]
Fu, Rongrong [2 ]
Yan, Bo [1 ]
Wang, Xiaobing [3 ]
Shu, Jicheng [2 ]
Deng, Jiao [1 ]
Huang, Huilian [2 ]
机构：
[1] Jiangxi Univ Tradit Chinese Med, Coll Pharm, Nanchang 330004, Jiangxi, Peoples R China
[2] Jiangxi Univ Tradit Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China
[3] China Pharmaceut Univ, State Key Lab Nat Med, Dept Nat Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China
来源：
FITOTERAPIA | 2019年 / 137卷
基金：
中国国家自然科学基金;
关键词：
Tinospora sinensis; Sesquiterpene glycoside; Amide;
D O I：
10.1016/j.fitote.2019.104247
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new sesquiterpene glycoside and a new amide have been isolated from the stems of Tinospora sinensis. Their structures were established by 2D NMR spectroscopic techniques (H-1,H-1-COSY, NOESY, HSQC and HMBC) and mass spectrometry. The isolated compounds were subjected to evaluate neuroprotective activities in vitro. The pre-treatment of two new compounds can significantly ameliorate damage of oxidative stress induced by A beta(25-35) and improve PC12 cells survival.
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收藏
页数：7
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