Cordifolide A, a Sulfur-Containing Clerodane Diterpene Glycoside from Tinospora cordifolia

被引：29
|
作者：
Pan, Li [1 ]
Terrazas, Cesar [2 ]
Lezama-Davila, Claudio M. [2 ]
Rege, Nirmala [4 ]
Gallucci, Judith C. [3 ]
Satoskar, Abhay R. [2 ]
Kinghorn, A. Douglas [1 ]
机构：
[1] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA
[2] Ohio State Univ, Dept Pathol, Coll Med, Columbus, OH 43210 USA
[3] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA
[4] Seth GS Med Coll & KEM Hosp, Dept Pharmacol, Bombay 400012, Maharashtra, India
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 08期
关键词：
DENDRITIC CELLS; GLUCOSIDES; CONSTITUENTS; RUMPHII; MIERS;
D O I：
10.1021/ol300657h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cordifolide A (1), a novel unprecedented sulfur-containing clerodane diterpene glycoside, together with other two new diterpene glycosides, cordifolides B (2) and C (3), and four known analogues, was isolated from a methanol-soluble extract of the stems of Tinospora cordifolia. The structures of the new compounds were determined on the basis of spectroscopic data interpretation, with that of cordifolido A (1) confirmed by a single-crystal X-ray crystallographic analysis. All isolates were evaluated for their in vitro immunomodulatory activity using mouse bone marrow-derived dentritic cells (BMDCs).
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收藏
页码：2118 / 2121
页数：4
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