Cordifolide A, a Sulfur-Containing Clerodane Diterpene Glycoside from Tinospora cordifolia

被引：29

作者：

Pan, Li ^{[1
]}

Terrazas, Cesar ^{[2
]}

Lezama-Davila, Claudio M. ^{[2
]}

Rege, Nirmala ^{[4
]}

Gallucci, Judith C. ^{[3
]}

Satoskar, Abhay R. ^{[2
]}

Kinghorn, A. Douglas ^{[1
]}

机构：

[1] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Pathol, Coll Med, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

[4] Seth GS Med Coll & KEM Hosp, Dept Pharmacol, Bombay 400012, Maharashtra, India

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 08期

关键词：

DENDRITIC CELLS; GLUCOSIDES; CONSTITUENTS; RUMPHII; MIERS;

D O I：

10.1021/ol300657h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cordifolide A (1), a novel unprecedented sulfur-containing clerodane diterpene glycoside, together with other two new diterpene glycosides, cordifolides B (2) and C (3), and four known analogues, was isolated from a methanol-soluble extract of the stems of Tinospora cordifolia. The structures of the new compounds were determined on the basis of spectroscopic data interpretation, with that of cordifolido A (1) confirmed by a single-crystal X-ray crystallographic analysis. All isolates were evaluated for their in vitro immunomodulatory activity using mouse bone marrow-derived dentritic cells (BMDCs).

引用

页码：2118 / 2121

页数：4

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