acute severe asthma exacerbation;
near fatal asthma;
REGULATORY T-CELLS;
NEAR-FATAL ASTHMA;
RANDOMIZED CONTROLLED-TRIAL;
END-EXPIRATORY PRESSURE;
BLOOD EOSINOPHIL COUNT;
MECHANICALLY VENTILATED PATIENTS;
ENVIRONMENTAL TOBACCO-SMOKE;
HUMAN RHINOVIRUS INFECTION;
NITRIC-OXIDE MEASUREMENTS;
LIFE-THREATENING ASTHMA;
D O I:
10.3390/jcm8091283
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Asthma is a chronic airway inflammatory disease that is associated with variable expiratory flow, variable respiratory symptoms, and exacerbations which sometimes require hospitalization or may be fatal. It is not only patients with severe and poorly controlled asthma that are at risk for an acute severe exacerbation, but this has also been observed in patients with otherwise mild or moderate asthma. This review discusses current aspects on the pathogenesis and pathophysiology of acute severe asthma exacerbations and provides the current perspectives on the management of acute severe asthma attacks in the emergency department and the intensive care unit.
机构:
Univ Coll London Hosp NHS Trust, London Sarcoma Serv, London, EnglandUniv Coll London Hosp NHS Trust, London Sarcoma Serv, London, England
Ingley, Katrina M.
Maleddu, Alessandra
论文数: 0引用数: 0
h-index: 0
机构:
Univ Coll London Hosp NHS Trust, London Sarcoma Serv, London, EnglandUniv Coll London Hosp NHS Trust, London Sarcoma Serv, London, England
Maleddu, Alessandra
Le Grange, Franel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Coll London Hosp NHS Trust, London Sarcoma Serv, London, EnglandUniv Coll London Hosp NHS Trust, London Sarcoma Serv, London, England
Le Grange, Franel
Gerrand, Craig
论文数: 0引用数: 0
h-index: 0
机构:
Royal Natl Orthopaed Hosp NHS Trust, Dept Orthopaed Oncol, London Sarcoma Serv, Stanmore, Middx, EnglandUniv Coll London Hosp NHS Trust, London Sarcoma Serv, London, England
Gerrand, Craig
Bleyer, Archie
论文数: 0引用数: 0
h-index: 0
机构:
Oregon Hlth & Sci Univ, Portland, OR 97201 USAUniv Coll London Hosp NHS Trust, London Sarcoma Serv, London, England
Bleyer, Archie
Yasmin, Ephia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Coll London Hosp NHS Trust, ReproductiveMed Unit, London, EnglandUniv Coll London Hosp NHS Trust, London Sarcoma Serv, London, England
Yasmin, Ephia
Whelan, Jeremy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Coll London Hosp NHS Trust, London Sarcoma Serv, London, EnglandUniv Coll London Hosp NHS Trust, London Sarcoma Serv, London, England
Whelan, Jeremy
Strauss, Sandra J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Coll London Hosp NHS Trust, London Sarcoma Serv, London, England
UCL Canc Inst, London, EnglandUniv Coll London Hosp NHS Trust, London Sarcoma Serv, London, England
机构:
GSK, Real World Evidence, Stockley Pk, Uxbridge, Middx, England
AstraZeneca, Resp Epidemiol, Cambridge, EnglandGSK, Real World Evidence, Stockley Pk, Uxbridge, Middx, England
Mullerova, Hana
Cockle, Sarah M.
论文数: 0引用数: 0
h-index: 0
机构:
GSK House, Value Evidence & Outcomes, Brentford, Middx, EnglandGSK, Real World Evidence, Stockley Pk, Uxbridge, Middx, England
Cockle, Sarah M.
Gunsoy, Necdet B.
论文数: 0引用数: 0
h-index: 0
机构:
GSK, Value Evidence & Outcomes, Stockley Pk, Uxbridge, Middx, EnglandGSK, Real World Evidence, Stockley Pk, Uxbridge, Middx, England
Gunsoy, Necdet B.
Nelsen, Linda M.
论文数: 0引用数: 0
h-index: 0
机构:
GSK, Value Evidence & Outcomes, Collegeville, PA USAGSK, Real World Evidence, Stockley Pk, Uxbridge, Middx, England
Nelsen, Linda M.
Albers, Frank C.
论文数: 0引用数: 0
h-index: 0
机构:
GSK, Resp Med Franchise, Res Triangle Pk, NC USA
Avill US Inc, Med Dept, Northbrook, IL 60062 USAGSK, Real World Evidence, Stockley Pk, Uxbridge, Middx, England