Acute Severe Asthma in Adolescent and Adult Patients: Current Perspectives on Assessment and Management

被引：46

作者：

Kostakou, Eirini ^{[1
]}

Kaniaris, Evangelos ^{[1
]}

Filiou, Effrosyni ^{[1
]}

Vasileiadis, Ioannis ^{[1
]}

Katsaounou, Paraskevi ^{[2
]}

Tzortzaki, Eleni ^{[3
]}

Koulouris, Nikolaos ^{[1
]}

Koutsoukou, Antonia ^{[1
]}

Rovina, Nikoletta ^{[1
]}

机构：

[1] Univ Athens, Athens Sch Med, Sotiria Hosp, ICU,Dept Pulm Med 1, Athens 11527, Greece

[2] Univ Athens, Athens Sch Med, Evangelismos Hosp, ICU 1, Athens 11527, Greece

[3] Resp Outpatient Clin, Iraklion 71305, Greece

来源：

JOURNAL OF CLINICAL MEDICINE | 2019年 / 8卷 / 09期

关键词：

acute severe asthma exacerbation; near fatal asthma; REGULATORY T-CELLS; NEAR-FATAL ASTHMA; RANDOMIZED CONTROLLED-TRIAL; END-EXPIRATORY PRESSURE; BLOOD EOSINOPHIL COUNT; MECHANICALLY VENTILATED PATIENTS; ENVIRONMENTAL TOBACCO-SMOKE; HUMAN RHINOVIRUS INFECTION; NITRIC-OXIDE MEASUREMENTS; LIFE-THREATENING ASTHMA;

D O I：

10.3390/jcm8091283

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Asthma is a chronic airway inflammatory disease that is associated with variable expiratory flow, variable respiratory symptoms, and exacerbations which sometimes require hospitalization or may be fatal. It is not only patients with severe and poorly controlled asthma that are at risk for an acute severe exacerbation, but this has also been observed in patients with otherwise mild or moderate asthma. This review discusses current aspects on the pathogenesis and pathophysiology of acute severe asthma exacerbations and provides the current perspectives on the management of acute severe asthma attacks in the emergency department and the intensive care unit.

引用

页数：44

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