Metal-free trifluoroethylation of activated alkenes: rapid access to construct fluorinated 3,3-disubstituted 2-oxindoles

被引：18

作者：

Mai, Wen-Peng ^{[1
]}

Sun, Bin ^{[1
]}

Qian, Guan-Sheng ^{[2
]}

Yuan, Jin-Wei ^{[1
]}

Mao, Pu ^{[1
]}

Yang, Liang-Ru ^{[1
]}

Xiao, Yong-Mei ^{[1
]}

机构：

[1] Henan Univ Technol, Sch Chem & Chem Engn, Zhengzhou 450001, Henan, Peoples R China

[2] South Cent Univ Nationalities, Coll Chem & Mat Sci, Wuhan 430074, Peoples R China

来源：

TETRAHEDRON | 2015年 / 71卷 / 44期

基金：

中国国家自然科学基金;

关键词：

Metal-free; C-H functionalization; Fluorination; Radical; Cyclization; RADICAL TANDEM CYCLIZATION; N-ARYLACRYLAMIDES; CF3-CONTAINING OXINDOLES; GENERAL-METHODS; TRIFLUOROMETHYLATION; BOND; PERFLUOROALKYLATION; 1,2-ALKYLARYLATION; ACRYLAMIDES; REAGENT;

D O I：

10.1016/j.tet.2015.09.004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and mild fluorination/cyclization reaction of activated alkenes under metal-free conditions has been developed. Fluorinated radicals were produced from halogenated hydrocarbons by simple rongalit, meanwhile, no metal and extra base are needed. This method provides a general and rapid route to construct fluorinated 2-oxindoles in aqueous solution. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：8416 / 8423

页数：8

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