Metal-free trifluoroethylation of activated alkenes: rapid access to construct fluorinated 3,3-disubstituted 2-oxindoles

被引：18
|
作者：
Mai, Wen-Peng [1 ]
Sun, Bin [1 ]
Qian, Guan-Sheng [2 ]
Yuan, Jin-Wei [1 ]
Mao, Pu [1 ]
Yang, Liang-Ru [1 ]
Xiao, Yong-Mei [1 ]
机构：
[1] Henan Univ Technol, Sch Chem & Chem Engn, Zhengzhou 450001, Henan, Peoples R China
[2] South Cent Univ Nationalities, Coll Chem & Mat Sci, Wuhan 430074, Peoples R China
来源：
TETRAHEDRON | 2015年 / 71卷 / 44期
基金：
中国国家自然科学基金;
关键词：
Metal-free; C-H functionalization; Fluorination; Radical; Cyclization; RADICAL TANDEM CYCLIZATION; N-ARYLACRYLAMIDES; CF3-CONTAINING OXINDOLES; GENERAL-METHODS; TRIFLUOROMETHYLATION; BOND; PERFLUOROALKYLATION; 1,2-ALKYLARYLATION; ACRYLAMIDES; REAGENT;
D O I：
10.1016/j.tet.2015.09.004
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and mild fluorination/cyclization reaction of activated alkenes under metal-free conditions has been developed. Fluorinated radicals were produced from halogenated hydrocarbons by simple rongalit, meanwhile, no metal and extra base are needed. This method provides a general and rapid route to construct fluorinated 2-oxindoles in aqueous solution. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8416 / 8423
页数：8
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