Facile One-Pot Synthesis of N-acyl-1H-1,2,3-benzotriazoles from Internal and Terminal Olefinic Fatty Acids and Their Antimicrobial Screening

被引：6

作者：

Rauf, Abdul ^{[1
]}

Gangal, Saloni ^{[1
]}

机构：

[1] Aligarh Muslim Univ, Dept Chem, Aligarh 202002, Uttar Pradesh, India

来源：

JOURNAL OF OLEO SCIENCE | 2008年 / 57卷 / 08期

关键词：

Fatty acids; N-acyl-1H-1,2,3-benzotriazoles; benzotriazole; thionyl chloride; antifungal activity;

D O I：

10.5650/jos.57.453

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

N-acyl-1H-1,2,3-benzotriazoles were prepared in good yields by the reaction of benzotriazole and thionyl chloride with olefinic fatty acids under mild reaction conditions. The new compounds 1-(undec-10-enoyl)-1H-1,2,3-benzotriazole (5a),1-[(Z)-octadec-9-enoyl]-1H-1,2,3-benzotriazole (5b), 1-[(9Z,12R)-12-hydroxyoctadec-9-enoyl]-1H-1,2,3-benzotriazole (5c), 1-[(9R,12Z)-9-hydroxyoctadec-12-enoyl]-1H-1,2,3-benzotriazole (5d) formed were characterized on the basis of elemental analysis and spectral data. All the newly synthesized compounds (5a-5d) were screened for their antimicrobial activity and showed good antifungal activity.

引用

页码：453 / 457

页数：5

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