Model mis-specification and overestimation of the intraclass correlation coefficient in cluster randomized trials

被引：12

作者：

Giraudeau, B

机构：

[1] Fac Med Tours, INSERM, CIC 202, F-37032 Tours, France

[2] Univ Paris 07, INSERM, Biostat & Epidemiol Clin, U 717, Paris, France

来源：

STATISTICS IN MEDICINE | 2006年 / 25卷 / 06期

关键词：

bias; cluster randomized trial; intraclass correlation coefficient; mixed-effects model; one-way random effects model;

D O I：

10.1002/sim.2260

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Intraclass correlation coefficient (ICC) estimates must be provided when reporting the results of a cluster randomized trial. This study demonstrates that estimating this parameter with one-way ANOVA and an underlying mixed-effects statistical model leads to biased estimates. The bias depends on the effect size of the studied treatment. Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：957 / 964

页数：8

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