Highly efficient amination in neat water of benzyl chlorides with dialkylformamides catalysed by N-heterocyclic carbene-palladium(II)-1-methylimidazole complex

被引：9

作者：

Chen, Wen-Xin ^{[1
]}

Zhang, Cai-Yun ^{[1
]}

Lu, Jian-Mei ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Chashan Univ Town, Wenzhou 325035, Zhejiang, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2013年 / 10期

基金：

中国国家自然科学基金;

关键词：

N-heterocyclic carbene; palladium complex; benzyl chlorides; amination; water; INDIRECT REDUCTIVE AMINATION; CROSS-COUPLING REACTIONS; CARBONYL-COMPOUNDS; ARYL CHLORIDES; BOND FORMATION; ALDEHYDES; KETONES; PRECATALYST; DERIVATIVES; INHIBITORS;

D O I：

10.3184/174751913X13787959859344

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dialkylformamides are excellent N-sources in the amination of benzyl chlorides when catalysed by a NHC-Pd(II)-Im complex. In the presence of NaOH and the catalyst, variously substituted benzyl chlorides and five different dialkylformamides reacted smoothly to afford the corresponding N,N-dialkyl-benzylamines in good to almost quantitative yields in eco-friendly solvent water at 50 degrees C within 3 h.

引用

页码：611 / 614

页数：4

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