Highly efficient amination in neat water of benzyl chlorides with dialkylformamides catalysed by N-heterocyclic carbene-palladium(II)-1-methylimidazole complex

被引：9
|
作者：
Chen, Wen-Xin [1 ]
Zhang, Cai-Yun [1 ]
Lu, Jian-Mei [1 ]
机构：
[1] Wenzhou Univ, Coll Chem & Mat Engn, Chashan Univ Town, Wenzhou 325035, Zhejiang, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2013年 / 10期
基金：
中国国家自然科学基金;
关键词：
N-heterocyclic carbene; palladium complex; benzyl chlorides; amination; water; INDIRECT REDUCTIVE AMINATION; CROSS-COUPLING REACTIONS; CARBONYL-COMPOUNDS; ARYL CHLORIDES; BOND FORMATION; ALDEHYDES; KETONES; PRECATALYST; DERIVATIVES; INHIBITORS;
D O I：
10.3184/174751913X13787959859344
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Dialkylformamides are excellent N-sources in the amination of benzyl chlorides when catalysed by a NHC-Pd(II)-Im complex. In the presence of NaOH and the catalyst, variously substituted benzyl chlorides and five different dialkylformamides reacted smoothly to afford the corresponding N,N-dialkyl-benzylamines in good to almost quantitative yields in eco-friendly solvent water at 50 degrees C within 3 h.
引用
收藏
页码：611 / 614
页数：4
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