Crucial amides for dimerization inhibitors of HIV-1 protease

被引：10
|
作者：
Bowman, MJ [1 ]
Chmielewski, J [1 ]
机构：
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 06期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.bmcl.2003.09.099
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An inhibitor based on crosslinked peptides from the interfacial region of HIV-1 protease, previously shown to act by dimerization inhibition, was modified by N-methylation to ascertain the importance of the amide hydrogens on inhibition. The effects of N-methylation on HIV-1 protease inhibition, as well as the effects on degradation by proteases are described. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1395 / 1398
页数：4
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