Crucial amides for dimerization inhibitors of HIV-1 protease

被引：10

作者：

Bowman, MJ ^{[1
]}

Chmielewski, J ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.bmcl.2003.09.099

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An inhibitor based on crosslinked peptides from the interfacial region of HIV-1 protease, previously shown to act by dimerization inhibition, was modified by N-methylation to ascertain the importance of the amide hydrogens on inhibition. The effects of N-methylation on HIV-1 protease inhibition, as well as the effects on degradation by proteases are described. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1395 / 1398

页数：4

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