DLRS: gene tree evolution in light of a species tree

被引:26
|
作者
Sjostrand, Joel [1 ,2 ]
Sennblad, Bengt [1 ,3 ]
Arvestad, Lars [1 ,2 ,4 ]
Lagergren, Jens [1 ,5 ]
机构
[1] Stockholm Univ, SE-17121 Solna, Sweden
[2] Stockholm Univ, Dept Numer Anal & Comp Sci, SE-10044 Stockholm, Sweden
[3] Karolinska Inst, Atherosclerosis Res Unit, Dept Med, SE-17177 Stockholm, Sweden
[4] KTH Royal Inst Technol, Swedish E Sci Res Ctr, SE-10044 Stockholm, Sweden
[5] KTH Royal Inst Technol, Sch Comp Sci & Commun, SE-10044 Stockholm, Sweden
基金
瑞典研究理事会;
关键词
DNA-SEQUENCES;
D O I
10.1093/bioinformatics/bts548
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
PrIME-DLRS (or colloquially: 'Delirious') is a phylogenetic software tool to simultaneously infer and reconcile a gene tree given a species tree. It accounts for duplication and loss events, a relaxed molecular clock and is intended for the study of homologous gene families, for example in a comparative genomics setting involving multiple species. PrIME-DLRS uses a Bayesian MCMC framework, where the input is a known species tree with divergence times and a multiple sequence alignment, and the output is a posterior distribution over gene trees and model parameters.
引用
收藏
页码:2994 / 2995
页数:2
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