DLRS: gene tree evolution in light of a species tree

被引：26

作者：

Sjostrand, Joel ^{[1
,2
]}

Sennblad, Bengt ^{[1
,3
]}

Arvestad, Lars ^{[1
,2
,4
]}

Lagergren, Jens ^{[1
,5
]}

机构：

[1] Stockholm Univ, SE-17121 Solna, Sweden

[2] Stockholm Univ, Dept Numer Anal & Comp Sci, SE-10044 Stockholm, Sweden

[3] Karolinska Inst, Atherosclerosis Res Unit, Dept Med, SE-17177 Stockholm, Sweden

[4] KTH Royal Inst Technol, Swedish E Sci Res Ctr, SE-10044 Stockholm, Sweden

[5] KTH Royal Inst Technol, Sch Comp Sci & Commun, SE-10044 Stockholm, Sweden

来源：

BIOINFORMATICS | 2012年 / 28卷 / 22期

基金：

瑞典研究理事会;

关键词：

DNA-SEQUENCES;

D O I：

10.1093/bioinformatics/bts548

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

PrIME-DLRS (or colloquially: 'Delirious') is a phylogenetic software tool to simultaneously infer and reconcile a gene tree given a species tree. It accounts for duplication and loss events, a relaxed molecular clock and is intended for the study of homologous gene families, for example in a comparative genomics setting involving multiple species. PrIME-DLRS uses a Bayesian MCMC framework, where the input is a known species tree with divergence times and a multiple sequence alignment, and the output is a posterior distribution over gene trees and model parameters.

引用

页码：2994 / 2995

页数：2

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