Rhapontigenin Converted from Rhapontin Purified from Rheum undulatum Enhances the Inhibition of Melanin Synthesis

被引：3

作者：

Lee, Hyun-Sun ^{[1
]}

Kim, Jeong-Keun ^{[2
]}

Park, Keun-Tae ^{[3
]}

Lim, Young-Hee ^{[3
]}

机构：

[1] Korea Univ, Inst Hlth Sci, Seoul 136703, South Korea

[2] Korea Polytech Univ, Dept Chem Engn & Biotechnol, Sihung Si 429793, Gyeonggi Do, South Korea

[3] Korea Univ, Dept Biomed Sci, Coll Hlth Sci, Seoul 136703, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2012年 / 76卷 / 12期

关键词：

rhapontigenin; bioconversion; tyrosinase; melanin synthesis inhibition; aglycone; MELANOGENESIS; BIOTRANSFORMATION; TYROSINASE;

D O I：

10.1271/bbb.120229

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rhapontigenin was produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation. Rhapontin and rhapontigenin exhibited dose-dependent inhibition of tyrosinase activity and melanin synthesis in B16F10 melanoma cells, but the inhibitory activity of rhapontigenin was greater than that of rhapontin. Thus the bioconversion of rhapontin enhanced its ability to inhibit cellular tyrosinase activity and melanin synthesis.

引用

页码：2307 / 2309

页数：3

共 50 条

[41] Tetra-aryl cyclobutane and stilbenes from the rhizomes of Rheum undulatum and their α-glucosidase inhibitory activity: Biological evaluation, kinetic analysis, and molecular docking simulation
Manh Tuan Ha
Kim, Minji
Kim, Chung Sub
Park, Se-Eun
Kim, Jeong Ah
Woo, Mi Hee
Choi, Jae Sue
Min, Byung Sun
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (08)
[42] Inhibition of melanin production by sesquiterpene lactones from Saussurea lappa and their analogues
Choodej, Siwattra
Pudhom, Khanitha
Yamauchi, Kosei
Mitsunaga, Tohru
MEDICINAL CHEMISTRY RESEARCH, 2019, 28 (06) : 857 - 862
[43] Inhibition of melanin production by sesquiterpene lactones from Saussurea lappa and their analogues
Siwattra Choodej
Khanitha Pudhom
Kosei Yamauchi
Tohru Mitsunaga
Medicinal Chemistry Research, 2019, 28 : 857 - 862
[44] Inhibition studies on LDH isoenzyme purified from uromastix testes
Javed, MUH
Waqar, MA
JOURNAL OF ENZYME INHIBITION, 1996, 10 (03): : 187 - 193
[45] Inhibition of Polyphenol Oxidase Purified from Potato (Solanum tuberosum)
Mercimek, Hatice Aysun
Guzeldag, Gulcihan
Ucan, Filiz
Guler, Kivilcim Caktu
Karaman, Muhammet
Karayilan, Ramazan
ROMANIAN BIOTECHNOLOGICAL LETTERS, 2015, 20 (06): : 10961 - 10968
[46] Activated phenoloxidase from Tenebrio molitor larvae enhances the synthesis of melanin by using a vitellogenin-like protein in the presence of dopamine
Lee, KM
Lee, KY
Choi, HW
Cho, MY
Kwon, TH
Kawabata, S
Lee, BL
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (12): : 3695 - 3703
[47] Fueling Melanocytes with ATP from Keratinocytes Accelerates Melanin Synthesis
Abdel-Malek, Zalfa A.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2019, 139 (07) : 1424 - 1426
[48] Comparison of protocols for removal of melanin from genomic DNA to optimize PCR amplification of DNA purified from highly pigmented lesions
Silva Almeida Vicentel, Anna Luiza
Bianchini, Raquel Alves
Laus, Ana Carolina
Macedo, Graziela
Reis, Rui Manuel
Vazquez, Vinicius de Lima
HISTOLOGY AND HISTOPATHOLOGY, 2019, 34 (09) : 1089 - 1096
[49] Anticancer effects of aloe-emodin from Rheum undulatum L. through activation of the p53 pathway in human prostate cancer cells
Tran, Nguyen Khoi Song
Nguyen, Nhu Quynh
Lee, Sullim
Kim, Seung Hyun
Jeong, Daesik
Seo, Eunjeong
Park, Jin Ju
Cho, Jaejin
Kang, Ki Sung
APPLIED BIOLOGICAL CHEMISTRY, 2024, 67 (01)
[50] Aloe-Emodin Isolated from Rheum Undulatum L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cellsfv
He, Mei Tong
Nguyen, Quynh Nhu
Cho, Eun Ju
Kim, Seung Hyun
Park, Seonju
Park, Jun Yeon
Lee, Sullim
Kang, Ki Sung
JOURNAL OF DIETARY SUPPLEMENTS, 2024, 21 (03) : 389 - 407

← 1 2 3 4 5 →