Rhapontigenin Converted from Rhapontin Purified from Rheum undulatum Enhances the Inhibition of Melanin Synthesis

被引：3
|
作者：
Lee, Hyun-Sun [1 ]
Kim, Jeong-Keun [2 ]
Park, Keun-Tae [3 ]
Lim, Young-Hee [3 ]
机构：
[1] Korea Univ, Inst Hlth Sci, Seoul 136703, South Korea
[2] Korea Polytech Univ, Dept Chem Engn & Biotechnol, Sihung Si 429793, Gyeonggi Do, South Korea
[3] Korea Univ, Dept Biomed Sci, Coll Hlth Sci, Seoul 136703, South Korea
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2012年 / 76卷 / 12期
关键词：
rhapontigenin; bioconversion; tyrosinase; melanin synthesis inhibition; aglycone; MELANOGENESIS; BIOTRANSFORMATION; TYROSINASE;
D O I：
10.1271/bbb.120229
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rhapontigenin was produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation. Rhapontin and rhapontigenin exhibited dose-dependent inhibition of tyrosinase activity and melanin synthesis in B16F10 melanoma cells, but the inhibitory activity of rhapontigenin was greater than that of rhapontin. Thus the bioconversion of rhapontin enhanced its ability to inhibit cellular tyrosinase activity and melanin synthesis.
引用
收藏
页码：2307 / 2309
页数：3
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