Liver injury due to 3-amino-1-methyl-5H-pyrido [4,3-b] indole (Trp-P-2) and its prevention by miso

被引：1
|
作者：
Suzuki, Hiroyuki [1 ]
Sone, Hideyuki [1 ]
Kawamura, Ken [2 ]
Ishihara, Kazuo [1 ]
机构：
[1] Niigata Womens Coll, Dept Human Life & Environm Sci, Higashi Ku, Niigata 9508680, Japan
[2] Kagawa Nutr Univ, Dept Publ Hlth, Saitama 3500288, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 08期
关键词：
3-amino-1-methyl-5H-pyrido [4,3-b] indole (Trp-P-2); miso; liver injury;
D O I：
10.1271/bbb.80253
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Trp-P-2(3-amino-1-methyl-5H-pyrido [4,3-b] indole) ingestion for 42 d by C3H/HeJJcl mice caused elevation of serum alanine transaminase (ALT) activity and several signs of liver injury. These alterations were not observed in mice fed the diet supplemented with 10% miso. This suggests a preventive effect of miso as to Trp-P-2 induced liver injury.
引用
收藏
页码：2236 / 2238
页数：3
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