Liver injury due to 3-amino-1-methyl-5H-pyrido [4,3-b] indole (Trp-P-2) and its prevention by miso

被引：1

作者：

Suzuki, Hiroyuki ^{[1
]}

Sone, Hideyuki ^{[1
]}

Kawamura, Ken ^{[2
]}

Ishihara, Kazuo ^{[1
]}

机构：

[1] Niigata Womens Coll, Dept Human Life & Environm Sci, Higashi Ku, Niigata 9508680, Japan

[2] Kagawa Nutr Univ, Dept Publ Hlth, Saitama 3500288, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 08期

关键词：

3-amino-1-methyl-5H-pyrido [4,3-b] indole (Trp-P-2); miso; liver injury;

D O I：

10.1271/bbb.80253

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trp-P-2(3-amino-1-methyl-5H-pyrido [4,3-b] indole) ingestion for 42 d by C3H/HeJJcl mice caused elevation of serum alanine transaminase (ALT) activity and several signs of liver injury. These alterations were not observed in mice fed the diet supplemented with 10% miso. This suggests a preventive effect of miso as to Trp-P-2 induced liver injury.

引用

页码：2236 / 2238

页数：3

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