A novel metallo-β-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem

被引：10
|
作者：
Shigemoto, Norifumi [1 ,2 ,3 ]
Kayama, Shizuo [1 ,2 ]
Kuwahara, Ryuichi [1 ,2 ,4 ]
Hisatsune, Junzo [1 ,2 ]
Kato, Fuminori [1 ,2 ]
Nishio, Hisaaki [5 ]
Yamasaki, Katsutoshi [6 ]
Wada, Yasunao [7 ]
Sueda, Taijiro [3 ]
Ohge, Hiroki [1 ,8 ]
Sugai, Motoyuki [1 ,2 ]
机构：
[1] Hiroshima Univ, Project Res Ctr Nosocomial Infect Dis, Minami Ku, Hiroshima 7348551, Japan
[2] Hiroshima Univ, Dept Bacteriol, Grad Sch Biomed & Hlth Sci, Minami Ku, Hiroshima 7348551, Japan
[3] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Surg, Minami Ku, Hiroshima 7348551, Japan
[4] West Japan Railway Co, Hiroshima Gen Hosp, Clin Lab, Higashi Ku, Hiroshima 7320057, Japan
[5] Shiga Med Ctr Adults, Clin Lab, Moriyama, Shiga 5248524, Japan
[6] Wakayama Rosai Hosp, Dept Clin Lab, Wakayama 6408505, Japan
[7] Hyogo Med Univ Hosp, Clin Lab, Nishinomiya, Hyogo 6638501, Japan
[8] Hiroshima Univ Hosp, Div Infect Dis, Hiroshima 7348551, Japan
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2013年 / 76卷 / 01期
关键词：
metallo-beta-lactamase; Klebsiella; resistance; bla(IMP-34); PSEUDOMONAS-AERUGINOSA; GENE CASSETTE; BLA(IMP-6); MEROPENEM; SINGAPORE;
D O I：
10.1016/j.diagmicrobio.2013.02.030
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We investigated 5 metallo-p-lactamase (MBL)-positive Klebsiella isolates from Japan showing intermediate resistance to imipenem. Sequencing of the MBL gene identified a novel variant of IMP-1 with a single amino acid substitution, Glu87Gly. This variant is designated as IMP-34 where bla(IMP-34) is located on a transmissible plasmid. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：119 / 121
页数：3
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