A novel metallo-β-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem

被引：10

作者：

Shigemoto, Norifumi ^{[1
,2
,3
]}

Kayama, Shizuo ^{[1
,2
]}

Kuwahara, Ryuichi ^{[1
,2
,4
]}

Hisatsune, Junzo ^{[1
,2
]}

Kato, Fuminori ^{[1
,2
]}

Nishio, Hisaaki ^{[5
]}

Yamasaki, Katsutoshi ^{[6
]}

Wada, Yasunao ^{[7
]}

Sueda, Taijiro ^{[3
]}

Ohge, Hiroki ^{[1
,8
]}

Sugai, Motoyuki ^{[1
,2
]}

机构：

[1] Hiroshima Univ, Project Res Ctr Nosocomial Infect Dis, Minami Ku, Hiroshima 7348551, Japan

[2] Hiroshima Univ, Dept Bacteriol, Grad Sch Biomed & Hlth Sci, Minami Ku, Hiroshima 7348551, Japan

[3] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Surg, Minami Ku, Hiroshima 7348551, Japan

[4] West Japan Railway Co, Hiroshima Gen Hosp, Clin Lab, Higashi Ku, Hiroshima 7320057, Japan

[5] Shiga Med Ctr Adults, Clin Lab, Moriyama, Shiga 5248524, Japan

[6] Wakayama Rosai Hosp, Dept Clin Lab, Wakayama 6408505, Japan

[7] Hyogo Med Univ Hosp, Clin Lab, Nishinomiya, Hyogo 6638501, Japan

[8] Hiroshima Univ Hosp, Div Infect Dis, Hiroshima 7348551, Japan

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2013年 / 76卷 / 01期

关键词：

metallo-beta-lactamase; Klebsiella; resistance; bla(IMP-34); PSEUDOMONAS-AERUGINOSA; GENE CASSETTE; BLA(IMP-6); MEROPENEM; SINGAPORE;

D O I：

10.1016/j.diagmicrobio.2013.02.030

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We investigated 5 metallo-p-lactamase (MBL)-positive Klebsiella isolates from Japan showing intermediate resistance to imipenem. Sequencing of the MBL gene identified a novel variant of IMP-1 with a single amino acid substitution, Glu87Gly. This variant is designated as IMP-34 where bla(IMP-34) is located on a transmissible plasmid. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：119 / 121

页数：3

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