Base-promoted [4+2] annulation of pyrrole-2-carbaldehyde derivatives with β,γ-unsaturated α-ketoesters: syntheses of 5,6-dihydroindolizines

被引：8

作者：

Zhang, You-Ya ^{[1
]}

Li, Lin ^{[1
]}

Ma, Ai-Jun ^{[1
]}

Wang, Wei-Feng ^{[1
,2
,3
]}

Peng, Jin-Bao ^{[1
]}

机构：

[1] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Guangdong, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[3] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 44期

关键词：

D TRIMETHYL ETHER; ONE-POT SYNTHESIS; CATALYZED SYNTHESIS; POLYSUBSTITUTED INDOLIZINES; LAMELLARIN D; CONSTRUCTION; CYCLIZATION; PYRROLE; ACCESS;

D O I：

10.1039/d2ob01903e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A base-promoted [4 + 2] annulation of pyrrole-2-carbaldehyde derivatives with beta,gamma-unsaturated alpha-ketoesters for the syntheses of multisubstituted 5,6-dihydroindolizines was developed. Using DBN as a base, the reaction proceeds smoothly under mild conditions to provide the target products in moderate to high yields, and many useful functional groups can be tolerated.

引用

页码：8633 / 8637

页数：5

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