Base-promoted [4+2] annulation of pyrrole-2-carbaldehyde derivatives with β,γ-unsaturated α-ketoesters: syntheses of 5,6-dihydroindolizines

被引：8
|
作者：
Zhang, You-Ya [1 ]
Li, Lin [1 ]
Ma, Ai-Jun [1 ]
Wang, Wei-Feng [1 ,2 ,3 ]
Peng, Jin-Bao [1 ]
机构：
[1] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Guangdong, Peoples R China
[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[3] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 44期
关键词：
D TRIMETHYL ETHER; ONE-POT SYNTHESIS; CATALYZED SYNTHESIS; POLYSUBSTITUTED INDOLIZINES; LAMELLARIN D; CONSTRUCTION; CYCLIZATION; PYRROLE; ACCESS;
D O I：
10.1039/d2ob01903e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A base-promoted [4 + 2] annulation of pyrrole-2-carbaldehyde derivatives with beta,gamma-unsaturated alpha-ketoesters for the syntheses of multisubstituted 5,6-dihydroindolizines was developed. Using DBN as a base, the reaction proceeds smoothly under mild conditions to provide the target products in moderate to high yields, and many useful functional groups can be tolerated.
引用
收藏
页码：8633 / 8637
页数：5
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