Synthesis of Homo- and Heterofunctionalized Glycoclusters and Binding to Pseudomonas aeruginosa Lectins PA-IL and PA-IIL

被引：29

作者：

Gerland, Beatrice ^{[2
]}

Goudot, Alice ^{[1
]}

Pourceau, Gwladys ^{[2
]}

Meyer, Albert ^{[2
]}

Vidal, Sebastien ^{[3
]}

Souteyrand, Eliane ^{[1
]}

Vasseur, Jean-Jacques ^{[2
]}

Chevolot, Yann ^{[1
]}

Morvan, Francois ^{[2
]}

机构：

[1] Univ Lyon, Ecole Cent Lyon, CNRS, INL,UMR 5270, F-69134 Ecully, France

[2] Univ Montpellier 2, Univ Montpellier 1, CNRS, IBMM,UMR 5247, F-34095 Montpellier 5, France

[3] Univ Lyon 1, CNRS, Lab Chim Organ Glycochim 2, ICBMS,UMR 5246, F-69622 Villeurbanne, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 17期

关键词：

CARBOHYDRATE-PROTEIN INTERACTIONS; DNA-DIRECTED IMMOBILIZATION; CLICK CHEMISTRY; GLYCOPEPTIDE DENDRIMERS; SOLID SUPPORT; HIGH-AFFINITY; OLIGONUCLEOTIDES; RECOGNITION; PHOSPHORAMIDITE; LIGANDS;

D O I：

10.1021/jo300826u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Homo- and heterofunctionalized glycoclusters with galactose and/or fucose residues targeting both PA-IL and PA-IIL lectins of Pseudomonas aeruginosa were synthesized using "Click" chemistry and DNA chemistry. Their binding to lectins (separately or in a mixture) was studied using a DNA Directed Immobilization carbohydrate microarray. Homoglycoclusters bind selectively to their lectin while the heteroglycocluster binds simultaneously both lectins with a slight lower affinity.

引用

页码：7620 / 7626

页数：7

共 47 条

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