Discovery of imidazopyridine and imidazopyridazine inhibitors of PI3K

被引:0
|
作者
Han, Wooseok [1 ]
Pecchi, Sabina [1 ]
Burger, Matthew [1 ]
Lan, Jiong [1 ]
Smith, Aaron [1 ]
Knapp, Mark [1 ]
Huh, Kay [1 ]
De Menezes, Daniel Lopes [1 ]
Jansen, Johanna [1 ]
Merritt, Hanne [1 ]
Kaufman, Susan [1 ]
Voliva, Charles [1 ]
机构
[1] Novartis Inst Biomed Res, Emeryville, CA 94608 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
42-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [11] Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors
    Barlaam, Bernard
    Cosulich, Sabina
    Fitzek, Martina
    Germain, Herve
    Green, Stephen
    Hanson, Lyndsey L.
    Harris, Craig S.
    Hancox, Urs
    Hudson, Kevin
    Lambert-van der Brempt, Christine
    Lamorlette, Maryannick
    Magnien, Francoise
    Ouvry, Gilles
    Page, Ken
    Ruston, Linette
    Ward, Lara
    Delouvrie, Benedicte
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (13) : 3030 - 3035
  • [12] Discovery of novel PI3Kγ/δ inhibitors as potential agents for inflammation
    Ellard, Katie
    Sunose, Mihiro
    Bell, Kathryn
    Ramsden, Nigel
    Bergamini, Giovanna
    Neubauer, Gitte
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (14) : 4546 - 4549
  • [13] Discovery of fluoroquinolone derivatives as potent, selective inhibitors of PI3Kγ
    Sha, Shao
    Han, Hong-Wei
    Gao, Fei
    Liu, Tian-Bao
    Li, Zhen
    Xu, Chi
    Zhong, Wei-Qing
    Zhu, Hai-Liang
    MEDCHEMCOMM, 2015, 6 (11) : 2029 - 2035
  • [14] Advances in the Discovery of Novel Inhaled PI3Kδ Inhibitors for the Treatment of Asthma
    Wei, Jun
    Gu, Dongyan
    Yuan, Leer
    Sheng, Rong
    CURRENT MEDICINAL CHEMISTRY, 2023, 30 (17) : 1971 - 1992
  • [15] Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity
    Tian, Chengze
    Yang, Chengbin
    Wu, Tianze
    Lu, Mingzhu
    Chen, Yi
    Yang, Yongtai
    Liu, Xiaofeng
    Ling, Yun
    Deng, Mingli
    Jia, Yu
    Zhou, Yaming
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 48
  • [16] Discovery and optimization of a series of benzothiazole PI3K/mTOR dual inhibitors
    D'Angelo, Noel D.
    Kim, Tae-Seong
    Andrews, Kristin
    Booker, Shon K.
    Caenepeel, Sean
    Chen, Kui
    D'Amico, Derin
    Freeman, Dan
    Jiang, Jian
    Liu, Longbin
    McCarter, John D.
    Miguel, Tisha San
    Mullady, Erin L.
    Schrag, Michael
    Subramanian, Raju
    Tang, Jin
    Wahl, Robert C.
    Wang, Ling
    Whittington, Douglas A.
    Wu, Tian
    Xi, Ning
    Xu, Yang
    Yakowec, Peter
    Yang, Kevin
    Zalameda, Leeanne P.
    Zhang, Nancy
    Hughes, Paul
    Norman, Mark H.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [17] Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors
    Zhou, Hua
    McGowan, Meredeth A.
    Lipford, Kathryn
    Christopher, Matthew
    Fradera, Xavier
    Witter, David
    Lesburg, Charles A.
    Li, Chaomin
    Methot, Joey L.
    Lampe, John
    Achab, Abdelghani
    Shaffer, Lynsey
    Goldenblatt, Peter
    Shah, Sanjiv
    Bass, Alan
    Schroeder, Gottfried
    Chen, Dapeng
    Zeng, Haoyu
    Augustin, Martin A.
    Katz, Jason D.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (01)
  • [18] Discovery and Optimization of Pyridazinones as PI3Kδ Selective Inhibitors for Administration by Inhalation
    Bruno, Paolo
    Micoli, Alessandra
    Corsi, Mauro
    Pala, Daniele
    Guariento, Sara
    Fiorelli, Claudio
    Ronchi, Paolo
    Fioni, Alessandro
    Gallo, Paola Maria
    Marenghi, Giulia
    Bertolini, Serena
    Capacchi, Silvia
    Mileo, Valentina
    Biagetti, Matteo
    Capelli, Anna Maria
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (13) : 11103 - 11124
  • [19] From lab to clinic: The discovery and optimization journey of PI3K inhibitors
    Lian, Siyu
    Du, Zhenhua
    Chen, Qingqing
    Xia, Yu
    Miao, Xinxin
    Yu, Weiwei
    Sun, Qian
    Feng, Chong
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 277
  • [20] Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ
    Pujala, Brahmam
    Agarwal, Anil K.
    Middya, Sandip
    Banerjee, Monali
    Surya, Arjun
    Nayak, Anjan K.
    Gupta, Ashu
    Khare, Sweta
    Guguloth, Rambabu
    Randive, Nitin A.
    Shinde, Bharat U.
    Thakur, Anamika
    Patel, Dhananjay I.
    Raja, Mohd.
    Green, Michael J.
    Alfaro, Jennifer
    Avila, Patricio
    Perez de Arce, Felipe
    Almirez, Ramona G.
    Kanno, Stacy
    Bernales, Sebastian
    Hung, David T.
    Chakravarty, Sarvajit
    McCullagh, Emma
    Quinn, Kevin P.
    Rai, Roopa
    Pham, Son M.
    ACS MEDICINAL CHEMISTRY LETTERS, 2016, 7 (12): : 1161 - 1166